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ABO Blood Type and Hematoma Expansion After Intracerebral Hemorrhage: An Exploratory Analysis.

TitleABO Blood Type and Hematoma Expansion After Intracerebral Hemorrhage: An Exploratory Analysis.
Publication TypeJournal Article
Year of Publication2019
AuthorsRoh D, Martin A, Sun C-H, Eisenberger A, Boehme A, Elkind MSV, Pucci JU, Murthy S, Kamel H, Sansing L, Park S, Agarwal S, Connolly ESander, Claassen J, Hod E, Francis RO
JournalNeurocrit Care
Volume31
Issue1
Pagination66-71
Date Published2019 08
ISSN1556-0961
KeywordsABO Blood-Group System, Aged, Aged, 80 and over, Cerebral Hemorrhage, Cohort Studies, Female, Hematoma, Humans, Logistic Models, Male, Middle Aged, Neuroimaging, Risk Factors
Abstract

BACKGROUND/PURPOSE: Blood type has become an increasingly recognized risk factor for coagulopathy. We explored the association between blood type and hematoma expansion (HE) after intracerebral hemorrhage (ICH).

METHODS: Spontaneous ICH patients prospectively enrolled in an ongoing ICH cohort study at Columbia University Irving Medical Center from 2009 to 2016 were evaluated. Primary ICH patients with admission blood type testing were evaluated for HE differences, defined as > 33% relative HE. The association of blood type with radiographic HE outcomes was assessed using multivariable logistic regression models. The association of blood type and poor clinical outcomes using modified Rankin Scale (mRS 4-6) was additionally explored.

RESULTS: Of 272 ICH patients with blood type data and neuroimaging available to determine HE, there were 146 (54%) type-O, 82 (30%) type-A, 34 (13%) type-B, and 10 (3%) type-AB patients. No significant baseline demographic, clinical, or radiographic differences were noted between blood types. Type-B blood was associated with more HE compared to other blood types (OR 2.82; 95% CI 1.23-6.45) after adjusting for known covariates of HE (anticoagulant use, time to admission computed tomography scan, and baseline hematoma volume). No associations with blood type and poor 3 month mRS were identified, but these analyses were limited secondary to our smaller cohort.

CONCLUSIONS: There may be differences in HE after ICH in patients with different blood types. Further work is required to replicate these findings and identify the pathophysiologic mechanisms behind coagulopathy between blood types after ICH.

DOI10.1007/s12028-018-0655-0
Alternate JournalNeurocrit Care
PubMed ID30547310
PubMed Central IDPMC6565501
Grant ListUL1 TR001863 / TR / NCATS NIH HHS / United States
UL1 TR001873 / TR / NCATS NIH HHS / United States

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