Pfizer COVID-19 vaccine appointments are available to our patients. Sign up for Connect today to schedule your vaccination. Continue your routine care with us by scheduling an in-person appointment or Video Visit.

Caffeine does not affect susceptibility to cortical spreading depolarization in mice.

TitleCaffeine does not affect susceptibility to cortical spreading depolarization in mice.
Publication TypeJournal Article
Year of Publication2019
AuthorsYalcin N, Chen S-P, Yu ES, Liu T-T, Yen J-C, Atalay YB, Qin T, Celik F, van den Maagdenberg AMjm, Moskowitz MA, Ayata C, Eikermann-Haerter K
JournalJ Cereb Blood Flow Metab
Volume39
Issue4
Pagination740-750
Date Published2019 04
ISSN1559-7016
KeywordsAnimals, Caffeine, Cerebellar Ataxia, Cortical Spreading Depression, Mice, Mice, Inbred C57BL, Migraine Disorders, Migraine with Aura, Regional Blood Flow
Abstract

Several factors that modulate migraine, a common primary headache disorder, also affect susceptibility to cortical spreading depolarization (CSD). CSD is a wave of neuronal and glial depolarization and thought to underlie the migraine aura and possibly headache. Here, we tested whether caffeine, known to alleviate or trigger headache after acute exposure or chronic use/withdrawal, respectively, modulates CSD. We injected C57BL/6J mice with caffeine (30, 60, or 120 mg/kg; i.p.) once ( acute) or twice per day for one or two weeks ( chronic). Susceptibility to CSD was evaluated by measuring the electrical CSD threshold and by assessing KCl-induced CSD. Simultaneous laser Doppler flowmetry was used to assess CSD-induced cortical blood flow changes. Recordings were performed 15 min after caffeine/vehicle administration, or 24 h after the last dose of chronic caffeine in the withdrawal group. The latter paradigm was also tested in mice carrying the familial hemiplegic migraine type 1 R192Q missense mutation, considered a valid migraine model. Neither acute/chronic administration nor withdrawal of caffeine affected CSD susceptibility or related cortical blood flow changes, either in WT or R192Q mice. Hence, adverse or beneficial effects of caffeine on headache seem unrelated to CSD pathophysiology, consistent with the non-migrainous clinical presentation of caffeine-related headache.

DOI10.1177/0271678X18768955
Alternate JournalJ. Cereb. Blood Flow Metab.
PubMed ID29651899
PubMed Central IDPMC6446422

Weill Cornell Medicine Neurology 525 E. 68th St.
PO Box 117
New York, NY 10065 Phone: (212) 746-6575