Cerebral toxoplasmosis in a patient with multiple myeloma.

TitleCerebral toxoplasmosis in a patient with multiple myeloma.
Publication TypeJournal Article
Year of Publication2022
AuthorsParasram M, Arevalo-Perez J
JournalSurg Neurol Int
Date Published2022

Background: Cerebral toxoplasmosis is a rare complication of relapsed/refractory multiple myeloma (MM) after autologous stem cell transplant (SCT). Imaging characteristics can be helpful in leading to rapid diagnosis and treatment.

Case Description: A 76-year-old man with relapsed/refractory IgA kappa MM status post autologous SCT who presented to the hospital with altered mental status. His hospital course was complicated by rapid decompensation to obtundation requiring intubation. Magnetic resonance imaging (MRI) of the brain revealed numerous ring-enhancing lesions with eccentric target signs, which were concerning for cerebral toxoplasmosis. Diagnosis was confirmed with positive toxoplasma cerebrospinal fluid polymerase chain reaction test.

Conclusion: Cerebral toxoplasmosis should be considered in the differential diagnosis for MM patients who present with altered mental status and neurologic findings. The ring-enhancing lesion with eccentric target sign on MRI can be helpful in the diagnosis of cerebral toxoplasmosis.

Alternate JournalSurg Neurol Int
PubMed ID35673676
PubMed Central IDPMC9168334

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