|Title||Feasibility and reproducibility of whole brain myelin water mapping in 4 minutes using fast acquisition with spiral trajectory and adiabatic T2prep (FAST-T2) at 3T.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Nguyen TD, Deh K, Monohan E, Pandya S, Spincemaille P, Raj A, Wang Y, Gauthier SA|
|Journal||Magn Reson Med|
|Date Published||2016 08|
|Keywords||Adult, Algorithms, Body Water, Brain Chemistry, Diffusion Tensor Imaging, Feasibility Studies, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Male, Molecular Imaging, Multiple Sclerosis, Myelin Sheath, Phantoms, Imaging, Reproducibility of Results, Sensitivity and Specificity, Signal Processing, Computer-Assisted|
PURPOSE: To develop and measure the reproducibility of 4-min whole brain myelin water fraction (MWF) mapping using fast acquisition with spiral trajectory and T2prep (FAST-T2) sequence at 3T.
METHODS: Experiments were performed on phantoms, 13 volunteers, and 16 patients with multiple sclerosis. MWF maps were extracted using a spatially constrained non-linear algorithm. The proposed adiabatic modified BIR-4 (mBIR-4) T2prep was compared with the conventional composite T2prep (COMP). The effect of reducing the number of echo times (TEs) from 15 to 6 (reducing scan time from 10 to 4 min) was evaluated. Reproducibility was assessed using correlation analysis, coefficient of variation (COV), and Bland-Altman plots.
RESULTS: Compared with COMP, mBIR-4 provided more accurate T2 in phantoms and better MWF maps in human brains. Reducing the number of TEs had a negligible effect on MWF map quality, with a regional MWF difference of <0.8%. Regional MWFs obtained by repeated scans showed excellent correlation (R = 0.99), low COV (1.3%-2.4%), and negligible bias within ±1% limits of agreement. On a voxel-wise basis, the agreement remained strong (correlation R = 0.89 ± 0.03, bias = 0.01% ± 0.29%, limits of agreement = [-3.35% ± 0.73%, 3.33% ± 0.61%]).
CONCLUSION: Whole brain MWF mapping with adiabatic FAST-T2 is feasible in 4 min and provides good intrasite reproducibility. Magn Reson Med 76:456-465, 2016. © 2015 Wiley Periodicals, Inc.
|Alternate Journal||Magn Reson Med|
|PubMed Central ID||PMC5486993|
|Grant List||S10 OD021782 / OD / NIH HHS / United States|