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The future of stem cell therapies for Parkinson disease.

TitleThe future of stem cell therapies for Parkinson disease.
Publication TypeJournal Article
Year of Publication2020
AuthorsParmar M, Grealish S, Henchcliffe C
JournalNat Rev Neurosci
Volume21
Issue2
Pagination103-115
Date Published2020 02
ISSN1471-0048
KeywordsAnimals, Brain, Cell Differentiation, Dopaminergic Neurons, Humans, Parkinson Disease, Pluripotent Stem Cells, Stem Cell Transplantation, Translational Medical Research
Abstract

Cell-replacement therapies have long been an attractive prospect for treating Parkinson disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with Parkinson disease have been variable, in part owing to the limitations of fetal tissue as a cell source, relating to its availability and the lack of possibility for standardization and to variation in methods. Advances in developmental and stem cell biology have allowed the development of cell-replacement therapies that comprise dopamine neurons derived from human pluripotent stem cells, which have several advantages over fetal cell-derived therapies. In this Review, we critically assess the potential trajectory of this line of translational and clinical research and address its possibilities and current limitations and the broader range of Parkinson disease features that dopamine cell replacement based on generating neurons from human pluripotent stem cells could effectively treat in the future.

DOI10.1038/s41583-019-0257-7
Alternate JournalNat. Rev. Neurosci.
PubMed ID31907406

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