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Gadolinium-Enhancing Lesions Lead to Decreases in White Matter Tract Fractional Anisotropy in Multiple Sclerosis.

TitleGadolinium-Enhancing Lesions Lead to Decreases in White Matter Tract Fractional Anisotropy in Multiple Sclerosis.
Publication TypeJournal Article
Year of Publication2016
AuthorsChiang GC, Pinto S, Comunale JP, Gauthier SA
JournalJ Neuroimaging
Volume26
Issue3
Pagination289-95
Date Published2016 05
ISSN1552-6569
KeywordsAdult, Algorithms, Anisotropy, Brain, Corpus Callosum, Diffusion Tensor Imaging, Disease Progression, Female, Gadolinium, Humans, Image Enhancement, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Nerve Fibers, Myelinated, Prospective Studies, Pyramidal Tracts, White Matter
Abstract

PURPOSE: Although MRI identification of new lesions forms the basis for monitoring disease progression in multiple sclerosis patients, how lesion activity relates to longitudinal white matter changes in the brain is unknown. We hypothesized that patients with gadolinium-enhancing lesions would show greater longitudinal decline in fractional anisotropy in major tracts compared to those with stable disease.

METHODS: Thirty patients with relapsing-remitting multiple sclerosis were included in this study-13 had enhancing lesions at baseline and 17 did not. Each patient underwent at least two 3 Tesla contrast-enhanced MRI scans with a DTI sequence with a median interval of 2.1 years between scans. The forceps major and minor of the corpus callosum and the bilateral corticospinal tracts were selected as the major white matter tracts of interest. These tracts were reconstructed using region-of-interest placement on standard anatomical landmarks and a fiber assignment by continuous tracking algorithm using TrackVis (version 0.5.2.2) software. Mixed-effects regression models were used to determine the association between enhancing lesions and subsequent longitudinal change in fractional anisotropy.

RESULTS: In patients with enhancing lesions, there was greater decline in fractional anisotropy compared to those with stable disease in the forceps major (P = .026), right corticospinal tract (P = .032), and marginally in the left corticospinal tract (P = .050), but not the forceps minor (P = .11).

CONCLUSION: Fractional anisotropy of major white matter tracts declined more rapidly in patients with enhancing lesions, suggesting greater diffuse white matter injury with active inflammatory disease. DTI may provide a means of monitoring white matter injury following relapses.

DOI10.1111/jon.12309
Alternate JournalJ Neuroimaging
PubMed ID26458494
PubMed Central IDPMC4833697
Grant ListUL1 TR000457 / TR / NCATS NIH HHS / United States

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