Global cerebrospinal fluid as a zero-reference regularization for brain quantitative susceptibility mapping.

TitleGlobal cerebrospinal fluid as a zero-reference regularization for brain quantitative susceptibility mapping.
Publication TypeJournal Article
Year of Publication2022
AuthorsDimov AV, Nguyen TD, Spincemaille P, Sweeney EM, Zinger N, Kovanlikaya I, Kopell BH, Gauthier SA, Wang Y
JournalJ Neuroimaging
Volume32
Issue1
Pagination141-147
Date Published2022 Jan
ISSN1552-6569
KeywordsAlgorithms, Brain, Brain Mapping, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging
Abstract

BACKGROUND AND PURPOSE: The objective ofthis study was to demonstrate a global cerebrospinal fluid (CSF) method for a consistent and automated zero referencing of brain quantitative susceptibility mapping (QSM).

METHODS: Whole brain CSF mask was automatically segmented by thresholding the gradient echo transverse relaxation ( map, and regularization was employed to enforce uniform susceptibility distribution within the CSF volume in the field-to-susceptibility inversion. This global CSF regularization method was compared with a prior ventricular CSF regularization. Both reconstruction methods were compared in a repeatability study of 12 healthy subjects using t-test on susceptibility measurements, and in patient studies of 17 multiple sclerosis (MS) and 10 Parkinson's disease (PD) patients using Wilcoxon rank-sum test on radiological scores.

RESULTS: In scan-rescan experiments, global CSF regularization provided more consistent CSF volume as well as higher repeatability of QSM measurements than ventricular CSF regularization with a smaller bias: -2.7 parts per billion (ppb) versus -0.13 ppb (t-test p<0.05) and a narrower 95% limits of agreement: [-7.25, 6.99] ppb versus [-16.60, 11.19 ppb] (f-test p<0.05). In PD and MS patients, global CSF regularization reduced smoothly varying shadow artifacts and significantly improved the QSM quality score (p<0.001).

CONCLUSIONS: The proposed whole brain CSF method for QSM zero referencing improves repeatability and image quality of brain QSM compared to the ventricular CSF method.

DOI10.1111/jon.12923
Alternate JournalJ Neuroimaging
PubMed ID34480496
PubMed Central IDPMC8752493
Grant ListS10 OD021782 / OD / NIH HHS / United States
R01 NS105144 / NS / NINDS NIH HHS / United States
R21 AG067466 / AG / NIA NIH HHS / United States
R01 NS095562 / NS / NINDS NIH HHS / United States
R01 NS090464 / NS / NINDS NIH HHS / United States

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