Title | Global cerebrospinal fluid as a zero-reference regularization for brain quantitative susceptibility mapping. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Dimov AV, Nguyen TD, Spincemaille P, Sweeney EM, Zinger N, Kovanlikaya I, Kopell BH, Gauthier SA, Wang Y |
Journal | J Neuroimaging |
Volume | 32 |
Issue | 1 |
Pagination | 141-147 |
Date Published | 2022 Jan |
ISSN | 1552-6569 |
Keywords | Algorithms, Brain, Brain Mapping, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging |
Abstract | BACKGROUND AND PURPOSE: The objective ofthis study was to demonstrate a global cerebrospinal fluid (CSF) method for a consistent and automated zero referencing of brain quantitative susceptibility mapping (QSM). METHODS: Whole brain CSF mask was automatically segmented by thresholding the gradient echo transverse relaxation ( map, and regularization was employed to enforce uniform susceptibility distribution within the CSF volume in the field-to-susceptibility inversion. This global CSF regularization method was compared with a prior ventricular CSF regularization. Both reconstruction methods were compared in a repeatability study of 12 healthy subjects using t-test on susceptibility measurements, and in patient studies of 17 multiple sclerosis (MS) and 10 Parkinson's disease (PD) patients using Wilcoxon rank-sum test on radiological scores. RESULTS: In scan-rescan experiments, global CSF regularization provided more consistent CSF volume as well as higher repeatability of QSM measurements than ventricular CSF regularization with a smaller bias: -2.7 parts per billion (ppb) versus -0.13 ppb (t-test p<0.05) and a narrower 95% limits of agreement: [-7.25, 6.99] ppb versus [-16.60, 11.19 ppb] (f-test p<0.05). In PD and MS patients, global CSF regularization reduced smoothly varying shadow artifacts and significantly improved the QSM quality score (p<0.001). CONCLUSIONS: The proposed whole brain CSF method for QSM zero referencing improves repeatability and image quality of brain QSM compared to the ventricular CSF method. |
DOI | 10.1111/jon.12923 |
Alternate Journal | J Neuroimaging |
PubMed ID | 34480496 |
PubMed Central ID | PMC8752493 |
Grant List | S10 OD021782 / OD / NIH HHS / United States R01 NS105144 / NS / NINDS NIH HHS / United States R21 AG067466 / AG / NIA NIH HHS / United States R01 NS095562 / NS / NINDS NIH HHS / United States R01 NS090464 / NS / NINDS NIH HHS / United States |