|Title||Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM).|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Zhang Y, Gauthier SA, Gupta A, Comunale J, Chiang GChia-Yi, Zhou D, Chen W, Giambrone AE, Zhu W, Wang Y|
|Journal||J Magn Reson Imaging|
|Date Published||2016 08|
|Keywords||Adult, Aging, Algorithms, Brain, Disease Progression, Early Diagnosis, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Longitudinal Studies, Magnetic Fields, Male, Multiple Sclerosis, Reproducibility of Results, Sensitivity and Specificity, Subtraction Technique|
PURPOSE: To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM).
MATERIALS AND METHODS: The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced-with-Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow-up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t-test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change.
RESULTS: Lesion susceptibility values relative to normal-appearing white matter (NAWM) changed from 3.61 ± 6.11 ppb when enhanced-with-Gd at the baseline MRI to 20.42 ± 10.23 ppb when not-enhanced-with-Gd at the follow-up MRI (P < 0.001).
CONCLUSION: MS lesion susceptibility value increases significantly as the lesion evolves from enhanced-with-Gd to not-enhanced-with-Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426-432.
|Alternate Journal||J Magn Reson Imaging|
|PubMed Central ID||PMC4946979|
|Grant List||R01 EB013443 / EB / NIBIB NIH HHS / United States |
R01 NS090464 / NS / NINDS NIH HHS / United States
S10 RR025145 / RR / NCRR NIH HHS / United States