Title | Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Moodie J, Healy BC, Buckle GJ, Gauthier SA, Glanz BI, Arora A, Ceccarelli A, Tauhid S, Han X-M, Venkataraman A, Chitnis T, Khoury SJ, Guttmann CRG, Weiner HL, Neema M, Bakshi R |
Journal | J Neurol Sci |
Volume | 315 |
Issue | 1-2 |
Pagination | 49-54 |
Date Published | 2012 Apr 15 |
ISSN | 1878-5883 |
Keywords | Adult, Cohort Studies, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Prospective Studies, Retrospective Studies, Severity of Illness Index |
Abstract | BACKGROUND: We previously described a composite MRI scale combining T1-lesions, T2-lesions and whole brain atrophy in multiple sclerosis (MS): the magnetic resonance disease severity scale (MRDSS). OBJECTIVE: Test strength of the MRDSS vs. individual MRI measures for sensitivity to longitudinal change. METHODS: We studied 84 MS patients over a 3.2±0.3 year follow-up. Baseline and follow-up T2-lesion volume (T2LV), T1-hypointense lesion volume (T1LV), and brain parenchymal fraction (BPF) were measured. MRDSS was the combination of standardized T2LV, T1/T2 ratio and BPF. RESULTS: Patients had higher MRDSS at follow-up vs. baseline (p<0.001). BPF decreased (p<0.001), T1/T2 increased (p<0.001), and T2LV was unchanged (p>0.5). Change in MRDSS was larger than the change in MRI subcomponents. While MRDSS showed significant change in relapsing-remitting (RR) (p<0.001) and secondary progressive (SP) phenotypes (p<0.05), BPF and T1/T2 ratio changed only in RRMS (p<0.001). Longitudinal change in MRDSS was significantly different between RRMS and SPMS (p=0.0027); however, change in the individual MRI components did not differ. Evaluation with respect to predicting on-study clinical worsening as measured by EDSS revealed a significant association only for T2LV (p=0.038). CONCLUSION: Results suggest improved sensitivity of MRDSS to longitudinal change vs. individual MRI measures. MRDSS has particularly high sensitivity in RRMS. |
DOI | 10.1016/j.jns.2011.11.040 |
Alternate Journal | J Neurol Sci |
PubMed ID | 22209496 |
PubMed Central ID | PMC3319060 |
Grant List | R01 NS055083 / NS / NINDS NIH HHS / United States R01 NS055083-01A1 / NS / NINDS NIH HHS / United States 1R01NS055083-01 / NS / NINDS NIH HHS / United States |