Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study.

TitleMagnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study.
Publication TypeJournal Article
Year of Publication2012
AuthorsMoodie J, Healy BC, Buckle GJ, Gauthier SA, Glanz BI, Arora A, Ceccarelli A, Tauhid S, Han X-M, Venkataraman A, Chitnis T, Khoury SJ, Guttmann CRG, Weiner HL, Neema M, Bakshi R
JournalJ Neurol Sci
Volume315
Issue1-2
Pagination49-54
Date Published2012 Apr 15
ISSN1878-5883
KeywordsAdult, Cohort Studies, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Prospective Studies, Retrospective Studies, Severity of Illness Index
Abstract

BACKGROUND: We previously described a composite MRI scale combining T1-lesions, T2-lesions and whole brain atrophy in multiple sclerosis (MS): the magnetic resonance disease severity scale (MRDSS).

OBJECTIVE: Test strength of the MRDSS vs. individual MRI measures for sensitivity to longitudinal change.

METHODS: We studied 84 MS patients over a 3.2±0.3 year follow-up. Baseline and follow-up T2-lesion volume (T2LV), T1-hypointense lesion volume (T1LV), and brain parenchymal fraction (BPF) were measured. MRDSS was the combination of standardized T2LV, T1/T2 ratio and BPF.

RESULTS: Patients had higher MRDSS at follow-up vs. baseline (p<0.001). BPF decreased (p<0.001), T1/T2 increased (p<0.001), and T2LV was unchanged (p>0.5). Change in MRDSS was larger than the change in MRI subcomponents. While MRDSS showed significant change in relapsing-remitting (RR) (p<0.001) and secondary progressive (SP) phenotypes (p<0.05), BPF and T1/T2 ratio changed only in RRMS (p<0.001). Longitudinal change in MRDSS was significantly different between RRMS and SPMS (p=0.0027); however, change in the individual MRI components did not differ. Evaluation with respect to predicting on-study clinical worsening as measured by EDSS revealed a significant association only for T2LV (p=0.038).

CONCLUSION: Results suggest improved sensitivity of MRDSS to longitudinal change vs. individual MRI measures. MRDSS has particularly high sensitivity in RRMS.

DOI10.1016/j.jns.2011.11.040
Alternate JournalJ Neurol Sci
PubMed ID22209496
PubMed Central IDPMC3319060
Grant ListR01 NS055083 / NS / NINDS NIH HHS / United States
R01 NS055083-01A1 / NS / NINDS NIH HHS / United States
1R01NS055083-01 / NS / NINDS NIH HHS / United States

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