Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study.

TitleMagnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study.
Publication TypeJournal Article
Year of Publication2012
AuthorsMoodie J, Healy BC, Buckle GJ, Gauthier SA, Glanz BI, Arora A, Ceccarelli A, Tauhid S, Han X-M, Venkataraman A, Chitnis T, Khoury SJ, Guttmann CRG, Weiner HL, Neema M, Bakshi R
JournalJ Neurol Sci
Date Published2012 Apr 15
KeywordsAdult, Cohort Studies, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Prospective Studies, Retrospective Studies, Severity of Illness Index

BACKGROUND: We previously described a composite MRI scale combining T1-lesions, T2-lesions and whole brain atrophy in multiple sclerosis (MS): the magnetic resonance disease severity scale (MRDSS).

OBJECTIVE: Test strength of the MRDSS vs. individual MRI measures for sensitivity to longitudinal change.

METHODS: We studied 84 MS patients over a 3.2±0.3 year follow-up. Baseline and follow-up T2-lesion volume (T2LV), T1-hypointense lesion volume (T1LV), and brain parenchymal fraction (BPF) were measured. MRDSS was the combination of standardized T2LV, T1/T2 ratio and BPF.

RESULTS: Patients had higher MRDSS at follow-up vs. baseline (p<0.001). BPF decreased (p<0.001), T1/T2 increased (p<0.001), and T2LV was unchanged (p>0.5). Change in MRDSS was larger than the change in MRI subcomponents. While MRDSS showed significant change in relapsing-remitting (RR) (p<0.001) and secondary progressive (SP) phenotypes (p<0.05), BPF and T1/T2 ratio changed only in RRMS (p<0.001). Longitudinal change in MRDSS was significantly different between RRMS and SPMS (p=0.0027); however, change in the individual MRI components did not differ. Evaluation with respect to predicting on-study clinical worsening as measured by EDSS revealed a significant association only for T2LV (p=0.038).

CONCLUSION: Results suggest improved sensitivity of MRDSS to longitudinal change vs. individual MRI measures. MRDSS has particularly high sensitivity in RRMS.

Alternate JournalJ Neurol Sci
PubMed ID22209496
PubMed Central IDPMC3319060
Grant ListR01 NS055083 / NS / NINDS NIH HHS / United States
R01 NS055083-01A1 / NS / NINDS NIH HHS / United States
1R01NS055083-01 / NS / NINDS NIH HHS / United States

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