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Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease.

TitleMaternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2012
AuthorsMosconi L, Tsui W, Murray J, McHugh P, Li Y, Williams S, Pirraglia E, Glodzik L, De Santi S, Vallabhajosula S, de Leon MJ
JournalNeurobiol Aging
Volume33
Issue3
Pagination624.e1-9
Date Published2012 Mar
ISSN1558-1497
KeywordsAdult, Adult Children, Age of Onset, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Energy Metabolism, Female, Humans, Male, Maternal Age, Middle Aged, Mothers, Radionuclide Imaging, Retrospective Studies, Risk Factors
Abstract

Cognitively normal (NL) individuals with a maternal history of late-onset Alzheimer's disease (MH) show reduced brain glucose metabolism on FDG-PET as compared to those with a paternal history (PH) and those with negative family history (NH) of Alzheimer's disease (AD). This FDG-PET study investigates whether metabolic deficits in NL MH are associated with advancing maternal age at birth. Ninety-six NL individuals with FDG-PET were examined, including 36 MH, 24 PH, and 36 NH. Regional-to-whole brain gray matter standardized FDG uptake value ratios were examined for associations with parental age across groups using automated regions-of-interest and statistical parametric mapping. Groups were comparable for clinical and neuropsychological measures. Brain metabolism in AD-vulnerable regions was lower in MH compared to NH and PH, and negatively correlated with maternal age at birth only in MH. There were no associations between paternal age and metabolism in any group. Evidence for a maternally inherited, maternal age-related mechanism provides further insight on risk factors and genetic transmission in late-onset AD.

DOI10.1016/j.neurobiolaging.2011.03.003
Alternate JournalNeurobiol. Aging
PubMed ID21514691
PubMed Central IDPMC3155000
Grant ListR01 AG022374 / AG / NIA NIH HHS / United States
M01 RR000096 / RR / NCRR NIH HHS / United States
R01 AG035137 / AG / NIA NIH HHS / United States
R01 AG022374-07 / AG / NIA NIH HHS / United States
AG035137 / AG / NIA NIH HHS / United States
R21 AG032554 / AG / NIA NIH HHS / United States
R01 AG013616 / AG / NIA NIH HHS / United States
M01 RR000096-46 / RR / NCRR NIH HHS / United States
P30 AG008051 / AG / NIA NIH HHS / United States
R01 AG013616-21 / AG / NIA NIH HHS / United States
AG022374 / AG / NIA NIH HHS / United States
AG032554 / AG / NIA NIH HHS / United States
AG13616 / AG / NIA NIH HHS / United States
M01RR0096 / RR / NCRR NIH HHS / United States
R01 AG035137-01A1 / AG / NIA NIH HHS / United States
R21 AG032554-02 / AG / NIA NIH HHS / United States

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