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Mechanisms of Risk Reduction in the Clinical Practice of Alzheimer's Disease Prevention.

TitleMechanisms of Risk Reduction in the Clinical Practice of Alzheimer's Disease Prevention.
Publication TypeJournal Article
Year of Publication2018
AuthorsSchelke MW, Attia P, Palenchar DJ, Kaplan B, Mureb M, Ganzer CA, Scheyer O, Rahman A, Kachko R, Krikorian R, Mosconi L, Isaacson RS
JournalFront Aging Neurosci
Volume10
Pagination96
Date Published2018
ISSN1663-4365
Abstract

Alzheimer's disease (AD) is a neurodegenerative dementia that affects nearly 50 million people worldwide and is a major source of morbidity, mortality, and healthcare expenditure. While there have been many attempts to develop disease-modifying therapies for late-onset AD, none have so far shown efficacy in humans. However, the long latency between the initial neuronal changes and onset of symptoms, the ability to identify patients at risk based on family history and genetic markers, and the emergence of AD biomarkers for preclinical disease suggests that early risk-reducing interventions may be able to decrease the incidence of, delay or prevent AD. In this review, we discuss six mechanisms-dysregulation of glucose metabolism, inflammation, oxidative stress, trophic factor release, amyloid burden, and calcium toxicity-involved in AD pathogenesis that offer promising targets for risk-reducing interventions. In addition, we offer a blueprint for a multi-modality AD risk reduction program that can be clinically implemented with the current state of knowledge. Focused risk reduction aimed at particular pathological factors may transform AD to a preventable disorder in select cases.

DOI10.3389/fnagi.2018.00096
Alternate JournalFront Aging Neurosci
PubMed ID29706884
PubMed Central IDPMC5907312
Grant ListUL1 TR000457 / TR / NCATS NIH HHS / United States

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