Multiple sclerosis lesion geometry in quantitative susceptibility mapping (QSM) and phase imaging.

TitleMultiple sclerosis lesion geometry in quantitative susceptibility mapping (QSM) and phase imaging.
Publication TypeJournal Article
Year of Publication2015
AuthorsEskreis-Winkler S, Deh K, Gupta A, Liu T, Wisnieff C, Jin M, Gauthier SA, Wang Y, Spincemaille P
JournalJ Magn Reson Imaging
Date Published2015 Jul
KeywordsAdult, Aged, Algorithms, Brain, Diffusion Tensor Imaging, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Male, Middle Aged, Multiple Sclerosis, Reproducibility of Results, Sensitivity and Specificity, White Matter

PURPOSE: To demonstrate the phase and quantitative susceptibility mapping (QSM) patterns created by solid and shell spatial distributions of magnetic susceptibility in multiple sclerosis (MS) lesions.

MATERIALS AND METHODS: Numerical simulations and experimental phantoms of solid- and shell-shaped magnetic susceptibility sources were used to generate magnitude, phase, and QSM images. Imaging of 20 consecutive MS patients was also reviewed for this Institutional Review Board (IRB)-approved MRI study to identify the appearance of solid and shell lesions on phase and QSM images.

RESULTS: Solid and shell susceptibility sources were correctly reconstructed in QSM images, while the corresponding phase images depicted both geometries with shell-like patterns, making the underlying susceptibility distribution difficult to determine using phase alone. In MS patients, of the 60 largest lesions identified on T2 , 30 lesions were detected on both QSM and phase, of which 83% were solid and 17% were shells on QSM, and of which 30% were solid and 70% were shell on phase. Of the 21 shell-like lesions on phase, 76% appeared solid on QSM, 24% appeared shell on QSM. Of the five shell-like lesions on QSM, all were shell-like on phase.

CONCLUSION: QSM accurately depicts both solid and shell patterns of magnetic susceptibility, while phase imaging fails to distinguish them.

Alternate JournalJ Magn Reson Imaging
PubMed ID25174493
PubMed Central IDPMC4733654
Grant ListR01 NS072370 / NS / NINDS NIH HHS / United States
R01NS072370 / NS / NINDS NIH HHS / United States
R01EB013443 / EB / NIBIB NIH HHS / United States
R01 EB013443 / EB / NIBIB NIH HHS / United States
R01 NS090464 / NS / NINDS NIH HHS / United States

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