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Neurological Management of Von Hippel-Lindau Disease.

TitleNeurological Management of Von Hippel-Lindau Disease.
Publication TypeJournal Article
Year of Publication2016
AuthorsHodgson TS, Nielsen SM, Lesniak MS, Lukas RV
JournalNeurologist
Volume21
Issue5
Pagination73-8
Date Published2016 Sep
ISSN2331-2637
KeywordsAngiogenesis Inhibitors, Central Nervous System Neoplasms, Genetic Therapy, Hemangioblastoma, Humans, Neurosurgical Procedures, Radiosurgery, von Hippel-Lindau Disease
Abstract

Von Hippel-Lindau disease is a genetic condition due to mutation of the Von Hippel-Lindau gene, which leads to an increased risk in the development of hemangioblastomas of the brain and spinal cord. The pathophysiology of disease and its clinical manifestations, as they pertain to the general neurologist, are discussed. Therapeutic management of central nervous system hemangioblastomas ranging from neurosurgical resection, radiation therapy, and systemic therapies is reviewed.

DOI10.1097/NRL.0000000000000085
Alternate JournalNeurologist
PubMed ID27564075

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