Nutritional interventions for Alzheimer's prevention: a clinical precision medicine approach.

TitleNutritional interventions for Alzheimer's prevention: a clinical precision medicine approach.
Publication TypeJournal Article
Year of Publication2016
AuthorsSchelke MW, Hackett K, Chen JL, Shih C, Shum J, Montgomery ME, Chiang GC, Berkowitz C, Seifan A, Krikorian R, Isaacson RScott
JournalAnn N Y Acad Sci
Date Published2016 03
KeywordsAlzheimer Disease, Humans, Insulin Resistance, Nutritional Status, Oxidative Stress, Precision Medicine, Risk Reduction Behavior

Alzheimer's disease (AD) is a major source of morbidity and mortality, with the disease burden expected to rise as the population ages. No disease-modifying agent is currently available, but recent research suggests that nutritional and lifestyle modifications can delay or prevent the onset of AD. However, preventive nutritional interventions are not universally applicable and depend on the clinical profile of the individual patient. This article reviews existing nutritional modalities for AD prevention that act through improvement of insulin resistance, correction of dyslipidemia, and reduction of oxidative stress, and discusses how they may be modified on the basis of individual biomarkers, genetics, and behavior. In addition, we report preliminary results of clinical application of these personalized interventions at the first AD prevention clinic in the United States. The use of these personalized interventions represents an important application of precision medicine techniques for the prevention of AD that can be adopted by clinicians across disciplines.

Alternate JournalAnn. N. Y. Acad. Sci.
PubMed ID27116241
PubMed Central IDPMC5674531
Grant ListUL1 TR000457 / TR / NCATS NIH HHS / United States

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