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Relations between cortical thickness, serotonin 1A receptor binding, and structural connectivity: A multimodal imaging study.

TitleRelations between cortical thickness, serotonin 1A receptor binding, and structural connectivity: A multimodal imaging study.
Publication TypeJournal Article
Year of Publication2018
AuthorsPillai RLI, Malhotra A, Rupert DD, Weschler B, Williams JC, Zhang M, Yang J, J Mann J, Oquendo MA, Parsey RV, DeLorenzo C
JournalHum Brain Mapp
Date Published2018 02
KeywordsAdult, Brain, Carbon Radioisotopes, Depressive Disorder, Major, Diffusion Tensor Imaging, Female, Humans, Magnetic Resonance Imaging, Male, Multimodal Imaging, Neural Pathways, Organ Size, Piperazines, Positron-Emission Tomography, Pyridines, Radiopharmaceuticals, Receptor, Serotonin, 5-HT1A

Serotonin 1A (5-HT ) receptors play a direct role in neuronal development, cell proliferation, and dendritic branching. We hypothesized that variability in 5-HT binding can affect cortical thickness, and may account for a subtype of major depressive disorder (MDD) in which both are altered. To evaluate this, we measured cortical thickness from structural magnetic resonance imaging (MRI) and 5-HT binding by positron emission tomography (PET) in an exploratory study. To examine a range of 5-HT binding and cortical thickness values, we recruited 25 healthy controls and 19 patients with MDD. We hypothesized increased 5-HT binding in the raphe nucleus (RN) would be negatively associated with cortical thickness due to reduced serotonergic transmission. Contrary to our hypothesis, raphe 5-HT binding was positively correlated with cortical thickness in right posterior cingulate cortex (PCC), a region implicated in the default mode network. Cortical thickness was also positively correlated with 5-HT in each cortical region. We further hypothesized that the strength of 5-HT -cortical thickness correlation depends on the number of axons between the raphe nucleus and each region. To explore this we related 5-HT -cortical thickness correlation coefficients to the number of tracts connecting that region and the raphe, as measured by diffusion tensor imaging (DTI) in an independent sample. The 5-HT -cortical thickness association correlated significantly with the number of tracts to each region, supporting our hypothesis. We posit a defect in the raphe may affect the PCC within the default mode network in MDD through serotonergic fibers, resulting in increased ruminative processing.

Alternate JournalHum Brain Mapp
PubMed ID29323797
PubMed Central IDPMC5769701
Grant ListK01 MH091354 / MH / NIMH NIH HHS / United States
R01 MH040695 / MH / NIMH NIH HHS / United States
P50 MH062185 / MH / NIMH NIH HHS / United States
R01 MH090276 / MH / NIMH NIH HHS / United States
F30 MH109412 / MH / NIMH NIH HHS / United States
R01 MH074813 / MH / NIMH NIH HHS / United States

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