Renal hemodynamics in drug-overdosed patients.

TitleRenal hemodynamics in drug-overdosed patients.
Publication TypeJournal Article
Year of Publication1976
AuthorsGlauser FL, Smith WR, Siefkin A, Morton ME
JournalAm J Med Sci
Date Published1976 Sep-Oct
KeywordsAcute Kidney Injury, Adult, Barbiturates, Blood, Carbon Dioxide, Female, Glomerular Filtration Rate, Hemodynamics, Heroin, Humans, Hydrogen-Ion Concentration, Kidney, Male, Oxygen, Regional Blood Flow

Effective renal plasms flow (ERPF) and glomerular filtration rate (GFR), as determined by a radioisotopic method, were evaluated in seven heroin-overdosage patients (Group I) and 7 hypnotic-sedative-analgesic overdosage patients (Group II). No patient had evidence of shock. There was no significant intergroup differences in PaO2, PaCO2, pH, blood pressure, pulse rate, respiratory rate, cardiac output, or serum creatinine levels. Group I patients had lower ERPF and GFR compared to Group II (271 +/- 182.8 vs. 580 +/- 62 cc/min and 62.4 +/- 32.6 vs. 102.9 +/- 12.8 cc/min, respectively, p less than 0.005). We conclude that compared to hypnotic-sedative-analagesic overdosed patients heroin overdosed patients heroin overdosed patients have more profoundly altered renal hemodynamics.

Alternate JournalAm J Med Sci
PubMed ID12658

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