|Title||Short-Term Risk of Ischemic Stroke After Detection of Left Ventricular Thrombus on Cardiac Magnetic Resonance Imaging.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Merkler AE, Alakbarli J, Gialdini G, Navi BB, Murthy SB, Goyal P, Kim J, Devereux RB, Safford MM, Iadecola C, Kamel H, Weinsaft JW|
|Journal||J Stroke Cerebrovasc Dis|
|Date Published||2019 Apr|
|Keywords||Adult, Aged, Brain Ischemia, Echocardiography, Female, Heart Diseases, Heart Ventricles, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Prognosis, Retrospective Studies, Risk Assessment, Risk Factors, Stroke, Thrombosis, Time Factors, Ventricular Function, Left|
BACKGROUND: The short-term risk of ischemic stroke in patients with left ventricular (LV) thrombus identified via delayed-enhancement cardiac magnetic resonance (DE-CMR) imaging is uncertain.
METHODS: We performed a retrospective cohort study of patients who underwent DE-CMR for evaluation of LV systolic dysfunction at NewYork-Presbyterian Hospital/Weill Cornell between 2007 and 2016. We identified all hospitalized patients who had DE-CMR evidence of LV thrombus, and as controls, all hospitalized patients who had no DE-CMR evidence of LV thrombus; 2 control patients were randomly selected for each patient with LV thrombus. Our primary outcome was ischemic stroke prior to hospital discharge. Additionally, we compared the risk of stroke among patients with: (1) no LV thrombus, (2) LV thrombus by DE-CMR but not by echocardiography, and (3) LV thrombus by both DE-CMR and echocardiography.
RESULTS: We identified 33 patients with LV thrombus and 66 patients without LV thrombus on DE-CMR. Of the 33 patients with LV thrombus on DE-CMR, 13 had echocardiographic evidence of thrombus. Ischemic stroke occurred in 3 of 33 (9.1%; 95% CI, 1.9%-24.3%) patients with LV thrombus on DE-CMR. Ischemic stroke occurred in 0 of 66 (0%; 95% CI, 0%-5.4%) patients without LV thrombus on DE-CMR, 1 of 20 (5.0%; 95% CI, .1%-24.9%) patients with thrombus on DE-CMR but not echocardiogram, and 2 of 13 (15.4%; 95% CI, 1.9%-45.4%) patients with thrombus on both DE-CMR and echocardiogram (P value for comparison among groups, .02).
CONCLUSIONS: We found a 9% short-term risk of ischemic stroke in patients with LV thrombus detected on DE-CMR.
|Alternate Journal||J Stroke Cerebrovasc Dis|
|PubMed Central ID||PMC6839765|
|Grant List||K23 HL140092 / HL / NHLBI NIH HHS / United States |
R01 NS037853 / NS / NINDS NIH HHS / United States
R01 NS073666 / NS / NINDS NIH HHS / United States
R01 NS097443 / NS / NINDS NIH HHS / United States
R01 HL128278 / HL / NHLBI NIH HHS / United States
UL1 TR002384 / TR / NCATS NIH HHS / United States
R01 HL080477 / HL / NHLBI NIH HHS / United States
KL2 TR002385 / TR / NCATS NIH HHS / United States
R37 NS089323 / NS / NINDS NIH HHS / United States
K23 NS082367 / NS / NINDS NIH HHS / United States
K23 NS091395 / NS / NINDS NIH HHS / United States
R01 NS034179 / NS / NINDS NIH HHS / United States
K23 NS105948 / NS / NINDS NIH HHS / United States
U01 NS095869 / NS / NINDS NIH HHS / United States