Toward Precision Phenotyping of Multiple Sclerosis.

TitleToward Precision Phenotyping of Multiple Sclerosis.
Publication TypeJournal Article
Year of Publication2022
AuthorsPitt D, Lo CHung, Gauthier SA, Hickman RA, Longbrake E, Airas LM, Mao-Draayer Y, Riley C, De Jager PLawrence, Wesley S, Boster A, Topalli I, Bagnato F, Mansoor M, Stuve O, Kister I, Pelletier D, Stathopoulos P, Dutta R, Lincoln MR
JournalNeurol Neuroimmunol Neuroinflamm
Date Published2022 Nov
KeywordsBiomarkers, Disease Progression, Humans, Inflammation, Multiple Sclerosis, Multiple Sclerosis, Chronic Progressive, Nervous System Diseases

The classification of multiple sclerosis (MS) has been established by Lublin in 1996 and revised in 2013. The revision includes clinically isolated syndrome, relapsing-remitting, primary progressive and secondary progressive MS, and has added activity (i.e., formation of white matter lesions or clinical relapses) as a qualifier. This allows for the distinction between active and nonactive progression, which has been shown to be of clinical importance. We propose that a logical extension of this classification is the incorporation of additional key pathological processes, such as chronic perilesional inflammation, neuroaxonal degeneration, and remyelination. This will distinguish MS phenotypes that may present as clinically identical but are driven by different combinations of pathological processes. A more precise description of MS phenotypes will improve prognostication and personalized care as well as clinical trial design. Thus, our proposal provides an expanded framework for conceptualizing MS and for guiding development of biomarkers for monitoring activity along the main pathological axes in MS.

Alternate JournalNeurol Neuroimmunol Neuroinflamm
PubMed ID36041861
PubMed Central IDPMC9427000
Grant ListR01 NS123532 / NS / NINDS NIH HHS / United States
UL1 TR001863 / TR / NCATS NIH HHS / United States
R01 NS118886 / NS / NINDS NIH HHS / United States
R01 NS102267 / NS / NINDS NIH HHS / United States
P30 CA008748 / CA / NCI NIH HHS / United States
R01 NS112907 / NS / NINDS NIH HHS / United States

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