Pfizer COVID-19 vaccine appointments are available to our patients. Sign up for Connect today to schedule your vaccination. Continue your routine care with us by scheduling an in-person appointment or Video Visit.

Utility of the NIH Toolbox for assessment of prodromal Alzheimer's disease and dementia.

TitleUtility of the NIH Toolbox for assessment of prodromal Alzheimer's disease and dementia.
Publication TypeJournal Article
Year of Publication2018
AuthorsHackett K, Krikorian R, Giovannetti T, Meléndez-Cabrero J, Rahman A, Caesar EE, Chen JL, Hristov H, Seifan A, Mosconi L, Isaacson RS
JournalAlzheimers Dement (Amst)
Volume10
Pagination764-772
Date Published2018
ISSN2352-8729
Abstract

Introduction: The NIH Toolbox Cognition Battery (NIHTB-CB) is a computer-based protocol not yet validated for clinical assessment.

Methods: We administered the NIHTB-CB and traditional neuropsychological tests to 247 Memory Disorders and Alzheimer's Prevention Clinic patients with subjective cognitive decline, mild cognitive impairment, mild dementia due to Alzheimer's disease, and normal cognition. Principal component analysis, partial correlations, and univariate general linear model tests were performed to assess construct validity. Discriminant function analyses compared classification accuracy.

Results: Principal component analysis identified three conceptually coherent factors: memory (MEM), executive function (EF), and crystallized intelligence (CI). These factors were strongly associated with corresponding traditional tests and differed across diagnostic groups as expected. Both NIHTB and traditional batteries yielded strong overall discriminative ability (>80%).

Discussion: The NIHTB-CB is a valid method to assess neurocognitive domains pertinent to aging and dementia and has utility for applications in a memory clinic setting.

DOI10.1016/j.dadm.2018.10.002
Alternate JournalAlzheimers Dement (Amst)
PubMed ID30505926
PubMed Central IDPMC6247399

Weill Cornell Medicine Neurology 525 E. 68th St.
PO Box 117
New York, NY 10065 Phone: (212) 746-6575